毛德奎 1秦海峰 2于爱平 3刘晋 2王沙沙 3高红军 3吴祖泽3
作者信息
- 1. 北京工业大学生命科学与生物工程学院,北京,100024
- 2. 军事医学科学院放射与辐射医学研究所,北京100850
- 3. 解放军307医院肿瘤内科,北京,100071
- 折叠
摘要
Abstract
Objective To evaluate the dynamic changes and clinical significance of coagulation, fibrinolytic markers and platelet parameters before and after chemotherapy in lung cancer patients. Methods The prothrombin time ( PT ), thrombin time ( TT ), activated partial thromboplastin time ( APTT ), fibrinogen ( FIB ), D-dimer ( D-D ), protein C ( PC ), free protein S ( FPS ), plasminogen activator inhibitor- I ( PAI- I ), platelet total ( PLT ), plateletcrit ( PCT ), mean platelet volume ( MPV ) and platelet distribution width ( PDW ) were measured in sixty lung cancer patients before and after chemotherapy, with twenty healthy people as control. Results Compared with the control group, the mean value of FIB, D-D, PAI- I , PLT, PCT and MPV were significantly increased ( P < 0. 05 or P < 0. 01 ) in patients with lung cancer while the mean value of PC and FPS was decreased ( P <0. 05 ). Compared with the pre-treatment patients, the mean value of PT, TT, APTT, FIB, D-D, PC, FPS, PLT, PCT and MPV was significantly decreased ( P < 0. 05 or P <0. 01 ) in post-treatment patients. However, the mean value of PAI- I was increased ( P <0. 01 ). There existed no relationship between the plasma level of coagulation, fibrinolytic markers, platelet parameters, sex, histological classification, TNM stages, and metastasis in lung cancer patients before or after chemotherapy( P > 0. 05 ). Conclusion The state ofhypercoagulability, secondary hyperfibrinolysis and low anticoagulation occur among patients with lung cancer. Chemotherapy may enhance blood coagulation functional disorders.关键词
肺癌/化疗/凝血/纤维蛋白原/血小板计数Key words
lung cancer/ chemotherapy/ coagulation/ fibrinogen/ platelet count分类
医药卫生
