军医进修学院学报2012，Vol.33Issue(1)：66-70,5.DOI:11-3275/R.20110708.0852.001
高温高湿环境对大鼠创伤性脑水肿的影响
Effect of high temperature and humidity environment on traumatic cerebral edema in rats
摘要
Abstract
Objective To analyze the effect of high temperature (HT) and high humidity(HH) environment on traumatic cerebral edema (TCE) by studying the influence of HT and HH environment on cerebral water content and AQP4 expression in rats with cerebral injury. Methods Sixty-four healthy adult male SD rats were randomly divided into normal temperature(25℃) group without traumatic injury(n=16), normal humidity (RH 50%) group with traumatic injury(n=16), HT(35℃) and HH (RH 85%) group without traumatic injury(n=16), and HT(35℃) and HH (RH 85%) group with traumatic injury(n=16). An acute cerebral injury model of rats was established with the free-falling body method. 6 and 24 hours after the rats in 4 groups were killed, cerebral water content and expression of AQP4 protein and mRNA were detected by electron microscopy with HE staining. Results The expression level of AQP4 and AQP4 mRNA and cerebral water content were significantly higher in normal temperature group with traumatic injury than in HT and HH groups with traumatic injury(P<0.01). Conclusion HT and HH environment can exacerbate TCE.关键词
创伤性脑水肿/高温/高湿Key words
traumatic brain edema/ hyperthermia/ high humidity分类
特种医学引用本文复制引用
马晓东,李扬,梁永平..高温高湿环境对大鼠创伤性脑水肿的影响[J].军医进修学院学报,2012,33(1):66-70,5.基金项目
全军医学科技"十一五"科研计划(06MA275) （06MA275）
