军医进修学院学报2012，Vol.33Issue(2)：105-107,3.DOI:11-3275/R.20110712.0826.001
中链甘油三酯对肥胖小鼠棕色脂肪及其β3肾上腺素能受体表达的影响
Effect of medium chain triglycerides on brown adipose tissue and its β 3 adrenergic receptors in mice with obesity induced by high fat diet
摘要
Abstract
Objective To observe the effect of medium chain triglycerides(MCT) on p 3 adrenergic receptors( β 3AR) in brown adipose tissue(BAT) of mice with obesity induced by high fat diet. Methods An obesity model of male C57BL/6J mice was induced by feeding high fat diet. Thirty obese mice were randomly divided into MCT group and long chain triglyceride(LCT) group(15 in each group) and fed with MCT and LCT, respectively, for 12 weeks. Body weight, body fat, blood lipid, brown fat mass, and β 3AR mRNA expression in BAT were observed before and after experiment. Results At the end of study, the body weight, body fat mass, serum levels of TG, TC, LDL-C were significantly lower while those of HDL-C and HDL-C/LDL-C were significantly higher in MCT group than in LCT group(P<0.05). The expression levels of cAMP, PKA, HSL, brown body fat mass, and β 3AR mRNA were significantly higher in MCT group than in LCT group(P<0.05). Conclusion MCT can promote the proliferation of BAT and up-regulate the β 3AR mRNA expression.关键词
中链甘油三酯/小鼠,肥胖/脂肪组织,棕色/β3肾上腺素能受体Key words
medium chain triglycerides/ mice, obese/ adipose tissue, brown/ β3 adrenergic receptor分类
医药卫生引用本文复制引用
张永,刘英华,张新胜,于晓明,徐庆,王觐,宫雪,杨雪艳,薛长勇..中链甘油三酯对肥胖小鼠棕色脂肪及其β3肾上腺素能受体表达的影响[J].军医进修学院学报,2012,33(2):105-107,3.基金项目
国家自然科学基金项目(81172667) （81172667）
