军医进修学院学报2012，Vol.33Issue(2)：158-160,3.
糖化血红蛋白与糖化白蛋白在诊断2型糖尿病中的价值比较
Value of HbA1c and glucoprotein for diagnosis of type 2 diabetes mellitus:A comparative study
郑华 1邹效漫 1马芳玲 1注僳安 1母义明1
作者信息
- 1. 解放军总医院 内分泌科 北京 100853
- 折叠
摘要
Abstract
Objective To study the reference value of HbAlc for diagnosis of type 2 diabetes mellitus(DM)and compare the sensitivity and reliability of glycosylated albumin(GA-L) and HbAlc in diagnosis of type 2 DM. Methods Five hundred and nine patients with type 2 DM(268 males and 241 females) were diagnosed according to the diagnostic criteria of American Diabetes Association (ADA). The sensitivity and reliability of GA-L and HbAlc in diagnosis of type 2 DM were analyzed and compared by plotting the receiver operating characteristic(ROC) curve for DM. Results The optimal cut point of HbAlc for diagnosis of type 2 DM was 6.75% with a sensitivity of 75.5% and a specificity of 93.2%. The area under the ROC curve was 0.886 with a positive likelihood ratio of 5.45 and a negative likelihood ratio of 0.23, a positive predictive value of 92% and a negative predicative value of 70%. The optimal cut point of GA-L was 17.45% with a sensitivity of 70.1% and a specificity of 91.6%. The area under the ROC curve was 0.844. When the optimal cut point of HbAlc and GA-L was ≥ 6.75% and ≥ 17.45%, its diagnosis accuracy was 94.9% and 93.3% respectively. Conclusion The HbAlc ≥ 6.75% and GA-L ≥ 17.45% can be used the reference values for the diagnosis of type 2 DM. The sensitivity and specificity of HbAlc are higher than those of GA-L in diagnosis of type 2 DM.关键词
糖化血红蛋白/糖化白蛋白/糖尿病/葡萄糖耐量试验(OGTT)/受试者工作特征曲线(ROC)Key words
glycated hemoglobin/ glycated albumin/ diabetes mellitus/ oral glucose tolerance test/ receiver operating characteristic curve分类
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郑华,邹效漫,马芳玲,注僳安,母义明..糖化血红蛋白与糖化白蛋白在诊断2型糖尿病中的价值比较[J].军医进修学院学报,2012,33(2):158-160,3.
