昆明医学院学报2011，Vol.32Issue(10)：36-40,5.
单侧髁突切除对非手术侧髁突软骨细胞增殖与凋亡的影响
Effect of Unilateral Condylectomy on the Proliferation and Apoptosis of the Opposite Condylar Chondrocytes
摘要
Abstract
Objective To investigate the effect of unilateral condylectomy on the proliferation and apoptosis of the opposite condylar chondrocytes. Methods Twenty-four 5-6 months old Japanese big-ear rabbits were randomly divided into 2 groups:the blank control group and the operation group. Rabbits in the opetation group were performed removing the right condylar. The left condylar (the nonoperative side) cartilages of each group were dissected in 2 months and 4 months after the operation accordingly. Immunohistochemical staining was used to qualitively examine the PCNA positive cell. TUNEL was chosen to detect the apoptotic cell. Results Immunohistochemical staining and TUNEL showed that: compared with the blank control group at the same time-points, the number of the PCNA positive cells decreased significantly in both 2 months and 4 months operation group; while the number of TUNEL positive cells increased significantly in both 2 months and 4 months operate group (P<0.05). Compared with the operation group in 2 months after the operation, the number of the PCNA positive cells decreased significantly in the operation group in 4 months after the operation; while the number of TUNEL positive cells increased significantly (P<0.05). Conclusion Unilateral condylectomy can decrese the proliferation capacity and increase apoptosis of the opposite condylar chondrocytes.关键词
髁突切除/软骨细胞/增殖/凋亡Key words
Condylectomy/ Chondrocyte/ Proliferation/ Apoptosis分类
医药卫生引用本文复制引用
廖立凡,曹小波,李松,罗应伟..单侧髁突切除对非手术侧髁突软骨细胞增殖与凋亡的影响[J].昆明医学院学报,2011,32(10):36-40,5.基金项目
云南省教育厅科学研究基金资助项目(08Z0036) （08Z0036）
云南省应用基础研究基金资助项目(2010C116) （2010C116）
