昆明医学院学报2011，Vol.32Issue(10)：124-127,4.
直癌患者血液高凝状态的相关性研究
Clinical Research of Blood Hypercoagulable State of Rectal Carcinoma Patients
王忠慧 1赵光瑜 1汪亚宏 1李珊珊1
作者信息
- 1. 昆明医学院第三附属医院,云南省肿瘤医院麻醉科,云南昆明 650118
- 折叠
摘要
Abstract
Objective To investigate platelet mobilizing function, blood clotting function and platelet correlated parametric detection index of rectal cancer patients and healthy volunteers, to dentify correlation of rectal carcinoma and blood hypercoagulable state. Methods We selected 89 rectal cancer patients confirmed by pathology as observation group and 40 healthy volunteers as the control. The expression of CD62P and CD63 in activated platelets, blood clotting function (TT, PT, APTT and FIB ) and platelet correlated parameters (PLT, PDW, MPV and P-LCR) of subjects in the two groups were measured. Results Compared with health volunteers, activation markers of platelet CD62p and CD63, platelet correlated parameters PLT, PDW, MPV, P-LCR and blood clotting function correlated parameter FIB were obviously increased (P< 0.01). The differences in TT, PT and APTT were not significant (P>0.05). Conclusions Rectal carcinoma patients usually have hypercoagulable states. The characters of hypercoagulable states are the increase of activation markers of platelet, platelet correlated parameters and blood clotting function correlated parameter FIB. Activation markers of platelet CD62p, CD63 are new senstive indexes to predict blood hypercoagulable state of rectal carcinoma patients.关键词
血液高凝/血小板活化/凝血参数/血小板参数Key words
Blood coagulation/ Platelet activation/ Coagulation parameters/ Platelet parameters分类
医药卫生引用本文复制引用
王忠慧,赵光瑜,汪亚宏,李珊珊..直癌患者血液高凝状态的相关性研究[J].昆明医学院学报,2011,32(10):124-127,4.
