昆明医学院学报2011，Vol.32Issue(11)：74-78,5.
血清同型半胱氨酸与冠脉病变的相关性研究
Association between Serum Homocyteine and Coronary Arteriosclerosis
郝应禄 1李燕萍 1杨娴 1钱宝堂 1余海 1谷青1
作者信息
- 1. 昆明医学院第六附属医院心内科,云南玉溪653100
- 折叠
摘要
Abstract
Objective To investigate the association between serum homocyteine ( Hcy) and coronary arteriosclerosis. Methods 340 patients in our hospital who had cronary anginography were divided into 4groups: stable angina (SA) group, unatable angina (UA) group, acute myocardial infarction (AMI) group and control group. Gensine score and the level of serum Hey were determinated in all cases. Results (1) Compared with control group, the serum Hey levels were significantly higher in all groups with coronary heart desease (P< 0.01) , increased in -UA group and AMI group than that of SA group (P< 0.01), higher in AMI group than that of UA group (P<0.01). (2) Mutiple stepwise linear regression analysis and Logistic regression analysis showed that after controlling the effects of sex, age, blood glucose, blood fat, etal, serum Hey was still associated with the severity and instability of coronary artery stenosis independently. (3) ROC curve showed the sensibility and specificity of serum Hey were better than low density lipoprotein cholestero and Gensine score. Conclusion It suggests that the increase of serum Hey level is associated with the severity of coronary arteriosclerosis.关键词
高同型半胱氨酸血症/同型半胱氨酸/冠心病Key words
Hyperhomocysteinemia/ Homocyeteine/ Coronary heart disease分类
医药卫生引用本文复制引用
郝应禄,李燕萍,杨娴,钱宝堂,余海,谷青..血清同型半胱氨酸与冠脉病变的相关性研究[J].昆明医学院学报,2011,32(11):74-78,5.
