兰州大学学报（医学版）2011，Vol.37Issue(4)：50-53,4.
皮质类固醇在体外循环下小儿心脏手术中作用的Meta分析
A Mate-analysis of prophylactic steroids for pediatric cardiac surgery
贾鹤龄 1张彬 2张斌飞 3杨克虎 4田金徽 4宋兵2
作者信息
- 1. 兰州大学第一医院麻醉科,甘肃兰州730000
- 2. 兰州大学第一医院心外科,甘肃兰州730000
- 3. 兰州大学第一临床医学院,甘肃兰州730000
- 4. 兰州大学基础医学院,甘肃兰州730000
- 折叠
摘要
Abstract
Objective To review systematically the beneficial and harmful effects of the prophylactic administration of corticosteroids, compared with placebo, in pediatric cardiac surgery. Methods The following databases were searched: PubMed (1956 to 2009-06), Cochrane library (3 issue, 2009), EMBASE(1974 to 2009-06), Chinese Biomedical Literature Database (1978 to 2009-06), Chinese Scientific Journals Fulltext Database (1989 to 2009-06), China Journal Fulltext Database (1994 to 2009-06). Two reviewers independently assessed trials for eligibility and quality, as well as the extracted data. Data were synthesized by using RevMan 5.0 software provided by the Cochrane Collaboration. Results A total of five trials (142 participants) were included for systematic review. Meta-analysis showed that perioperative use of corticosteroids can not be shortened intensive care unit stay[SMD -0.32, 95%CI (-0.69, 0.05), P=0.09] and duration of ventilation [SMD -0.11, 95%CI (-0.50, 0.29), P <0.59], reduce the peak core temperature [MD -0.52, 95%CI (-0.65, -0.39), P <0.00001]. Conclusion The use of prophylactic steroids in pediatric patients to reduce postoperative complications commonly following cardiopulmonary bypass surgery is not supported by the existing evidence. Further well-designed, adequately-powered and randomly controlled trials are needed to estimate more accurately the benefit and harm of this intervention.关键词
皮质类固醇/体外循环/小儿心脏手术/Meta分析Key words
corticosteroids/ extracorporeal circulation/ pediatric cardiac surgery/ Meta-analysis分类
医药卫生引用本文复制引用
贾鹤龄,张彬,张斌飞,杨克虎,田金徽,宋兵..皮质类固醇在体外循环下小儿心脏手术中作用的Meta分析[J].兰州大学学报（医学版）,2011,37(4):50-53,4.
