临床肝胆病杂志2011，Vol.27Issue(12)：1278-1281,1284,5.
ALT轻度升高、HBVDNA水平不同的慢性乙型肝炎患者肝组织学差异探讨
Study of liver pathology in mild ALT-elevated chronic hepatitis B patients with different HBV DNA levels
庄林 1游晶 2雷华 1李云丽 1孔蕾 1王晴晴 1胡明芬 1柏宝利1
作者信息
- 1. 昆明市第三人民医院肝病科,昆明650041
- 2. 昆明医学院第一附属医院感染性疾病科,昆明650032
- 折叠
摘要
Abstract
Objective To explore the difference of liver pathological changes in chronic hepatitis B (CHB) with mild alanine aminotrans-ferase ( ALT) - elevation and to provide evidence for solving the vital problems in antiviral therapy in patients with an ALT less than 80 U/L Methods One hundred and twenty CHB patients with mild ALT - elevation including HBeAg - positive and HBeAg - negative were divided into groups according to serum HBV DNA load and then the patients were sub - divided into two groups based on 2 times ULN ALT levels (80 U/L), which are group A with ALT^80 U/L and group B with ALT < 80 U/L. Transepidermal liver biopsy and histopathology examinations are conducted to compare the difference of pathologic grading and staging of hepatic inflammation and fibrosis between the two groups. Results The result shows that there is no significant differences of hepatic inflammation activity and hepatic fibrosis between group A (ALI>80 U/L) and group B (ALT < 80 U/L) with HBeAg - positive or HBeAg - negative for all groups of different HBV DNA groups ( P > 0.05 ). Conclusion In conclusion, the comparison of liver histology changes for both HBeAg - positive and HBeAg - negative CHB patients with different HBV DNA load indicate that no obvious differences of hepatic inflammation activity and hepatic fibrosis between ALT ≥80 U/L group and ALT < 80 U/L group. The present study provides an important evidence for antiviral treatment in chronic hepatitis B patients with an ALT less than 80 U/L.关键词
肝炎/乙型/慢性/丙氨酸转氨酶/肝炎病毒/乙型/DNA/病毒Key words
hepatitis B, chronic/ alanine aminotransferase/ hepatitis B virus/ DNA, viral分类
医药卫生引用本文复制引用
庄林,游晶,雷华,李云丽,孔蕾,王晴晴,胡明芬,柏宝利..ALT轻度升高、HBVDNA水平不同的慢性乙型肝炎患者肝组织学差异探讨[J].临床肝胆病杂志,2011,27(12):1278-1281,1284,5.
