临床口腔医学杂志2012，Vol.28Issue(1)：3-4,2.DOI:10.3969/j.issn.1003-1634.2012.01.002
OSCC中ER-α、RAR-β、MGMT及P16INK4a基因启动子甲基化的临床研究
Promoter hypermethylation profile of ER-α, RAR-β, MGMT and P16INK4a genes in oral squamous cell carcinoma
薛万林 1刘春利1
作者信息
- 1. 华中科技大学校医院口腔科 湖北武汉430030
- 折叠
摘要
Abstract
Objective: To explore the status of promoter hypermethylation of several genes in oral squamous cell carcinoma (OSCC). Method: In this study, the hypermethylation profile in the promoter region of P16INK4a,RAR-β. MGMT and ER-α genes was investigated in twenty male patients with primary OSCC and two OSCC cell lines. Result: The incidence of hypermethylation in patients was 10 % (2 of 20) for pl6INK4a, 10 % (2 of 20) for MGMT,40 % (8 of 20) for RAR-p and 55 % (11 of 20) for ER-αgene respectively. Aberrant promoter hypermethylation was found for RAR-β and ER-α genes,but not for P16INK4a and MGMT genes in both GNM and TSCCa cell lines. Conclusion: Our results indicate that epigenetic alteration of RAR-β and ER-α genes in OSCC is a more frequent event than P16INK4a and MGMT genes, suggesting the critical importance of promoter hypermethylation at RAR-β and ER-α genes.关键词
口腔鳞状细胞癌/启动子甲基化/癌基因Key words
oral squamous cell carcinomas (OSCC)/promoter hypermethylation /oncogene分类
生物科学引用本文复制引用
薛万林,刘春利..OSCC中ER-α、RAR-β、MGMT及P16INK4a基因启动子甲基化的临床研究[J].临床口腔医学杂志,2012,28(1):3-4,2.
