临床神经病学杂志2011，Vol.24Issue(6)：401-403,3.
广东汉族人群Toll样受体4基因多态性与颅内外动脉粥样硬化及脑梗死的关系
Relation of Toll-like receptor 4 gene polymorphisms to artherosclerosis and cerebral infarction in Guangdong Han population
摘要
Abstract
Objective To explore the relation of Toll-like receptor 4 ( TLR4) gene polymorphisms to artherosclerosis and cerebral infarction in Guangdong Han population. Methods Two hundred in-patients and outpatients were divided into 5 groups according to the clinical manifestations, the test results of skull imaging, digital subtraction angiography, carotid artery color dopplar ultrasound or transcranial doppler ultrasound and with the risk factories of stroke. ( 1 ) Group with cerebral infarction and features of artherosclerotic stenosis in intracranial or extracranial arteries (40 cases). (2) Group with cerebral infarction, but without features of artherosclerotic stenosis in intracranial or extracranial arteries (40 cases). ( 3 ) Group with features of artherosclerotic stenosis in intracranial or extracranial arteries, but without cerebral infarction (40 cases) . (4 ) Group with ≥ 3 risk factories for stroke, but without cerebral infarction or features of artherosclerotic stenosis in intracranial or extracranial arteries (40 cases). (5) Normal control group (40 cases). The polymorphisms of the TLR4 gene A299G and C399T were detected using gene sequencing method. Results The polymorphisms of the TLR4 gene A299G and C399T were not found out in any of the 5 groups. Conclusion There is no association between TLR4 gene A299G and C399T polymorphisms and artherosclerosis or cerebral infarction in Guangdong Han population.关键词
Toll样受体4/动脉粥样硬化/脑梗死/基因多态性Key words
toll-like receptor 4/ gene polymorphism/ artherosclerosis/ cerebral infarction分类
医药卫生引用本文复制引用
梁燕玲,许治强,匡永锋,刘宇明..广东汉族人群Toll样受体4基因多态性与颅内外动脉粥样硬化及脑梗死的关系[J].临床神经病学杂志,2011,24(6):401-403,3.基金项目
广东省科技计划项目(2009B030801352) （2009B030801352）
广州医学院博士启动课题(2006GD080) （2006GD080）
