摘要
Abstract
Objective To investigate clinical manifestations, treatment and prognosis of Landan-ldeffner syndrome (acquired epileptic aphasia LKS). Methods Clinical data of 4 patients with LKS were retrospectively analyzed. Results 2 cases were misdiagnosed as mental problem, and mental retardation. 2 cases were diagnosed as epilepsy, but treatment was not regular. All of them were diagnosed by electrocardiogram examination. After treatment of methylprednisolone and levetiracetam, the EEC returned to normal(2 cases) or showed improvement(2 cases) , and 3 cases of aphasia improved, but did not return to normal levels, and one case had no significant improvement. Conclusion The main clinical manifestation of LSK is seizures, aphasia and EEC abnormalitie, methylprednisolone shock-treatment, oral levetiracetam, and valproate treatment can control seizures. EEG may return to normal, and aphasia can be partially restored, but it is difficult to return to the premorbid level.关键词
Landau-kleffner综合征/失语/脑电图/诊断,鉴别/糖皮质激素/治疗Key words
LKS/ Aphasia/ Seizure/ Methylprednisolone/ Differential diagnosis/ Glucocorticoids/ Treatment分类
医药卫生
