临床误诊误治2012，Vol.25Issue(2)：29-31,3.DOI:10.3969/j.issn.1002-3429.2012.02.014
血清半胱氨酸蛋白酶抑制剂C评估有机磷中毒患者肾功能损害的临床价值
Clinical Value of Serum Cystatin C in Evaluation of Impairment of Renal Function in Patients with Acute Organophospho rus Pesticide Poisoning
摘要
Abstract
Objective To evaluate the clinical value of serum cystatin C in renal function in acute organophosphorus pesti cide poisoning (AOPP) patients. Methods 102 patients with AOPP in our hospital were recruited as AOPP group, blood urea ni trogen (BUN) , creatinine (Cr) and serum cystatin C were determined on the 1st and 3rd day. 120 healthy subjects were recruited as healthy control group, the blood test was taken in the outpatient department to detect these indicators. Results On the 1st and 3rd day after admission, the level of BUN and Cr of AOPP group was not statistically significant (P > 0.05) , but the levels of serum cystatin C showed significant difference (P < 0. 05) ; There was no significant difference in the level of BUN and Cr between AOPP group and healthy control group (P >0.05) , but the level of serum cystatin C showed significant difference (P <0. 05). On the 1st day after admission, the positive rate of serum cystatin C of AOPP group was 49.0% (50/102) , and the positive rate of BUN and Cr combined test was 18.6% (19/162); On the 3" day after admission, the positive rate of serum cystatin C was 98.0% (100/102) , and the positive rate of BUN and Cr combined test was 19.6% (20/102). Conclusion Serum cystatin C may register the early var iation of renal function, suggesting that the detection of cystatin C is of great clinical significance in estimating the renal insufficien cy and prognosis of the patients following AOPP.关键词
有机磷化合物/中毒/半胱氨酸蛋白酶抑制剂CKey words
Organophosphorus compound/ Poisoning/ Cystatin C分类
医药卫生引用本文复制引用
金欣,杨倩琳,陈建魁,于农,宋世平,左向华,尹秀云,黄媛,王淼,曾利军..血清半胱氨酸蛋白酶抑制剂C评估有机磷中毒患者肾功能损害的临床价值[J].临床误诊误治,2012,25(2):29-31,3.基金项目
国家科学技术部课题(2006FK130006) （2006FK130006）
