南京医科大学学报（自然科学版）2011，Vol.31Issue(11)：1550-1555,6.
脱氧鬼臼毒素对大鼠背根神经元电压依赖性钾通道的作用
The effects of deoxypodophyllotoxin on voltage-dependant K+ channels of rat dorsal root ganglion (DRG) neurons
摘要
Abstract
Objective :To investigate the mechanism of deoxypodophyllotoxin (DOP) against the peripheral nervous system. Meth-ods: The effects of DOP on voltage-dependant K+ channels were studied by using whole-cell patch-clamp recordings on acute isolated rat dorsal root ganglion (DRG) neurons. Results; DOP can reversibly block voltage-dependent potassium current (IK) and delayed-rectifier potassium current (Ikdr) and make the curve of the current-voltage relation shift to positive potentials at the concentration of 10,20,40 and 80 μmol/L This study thus demonstrated that DOP is a dose-dependant and reversibly blocker of IK and IKDR in DRG neurons. The inhibition rate of DOP on IKDR was higher than on Ik- Conclusion; It can be concluded that the effect of DOP on the current of potassium channel of DRC neurons may be a possible contributing mechanism for the toxin on peripheral nervous system.关键词
脱氧鬼臼毒素/背根神经节/钾通道/膜片钳Key words
deoxypodophyllotoxin/dorsal root ganglionneurons/K+ channels/patch-clamp分类
医药卫生引用本文复制引用
刘艳青,肖杭,程洁,王昌松,赵丽萍,王军,高蓉..脱氧鬼臼毒素对大鼠背根神经元电压依赖性钾通道的作用[J].南京医科大学学报（自然科学版）,2011,31(11):1550-1555,6.基金项目
国家自然科学基金资助(30671785 （）
30971939) （）
