南京医科大学学报（自然科学版）2011，Vol.31Issue(11)：1614-1619,6.
尿酸水平与代谢综合征多因素的相关性研究
The study of relevant factors in metabolic syndrome and hyperurcemia
摘要
Abstract
Objective: To investigate the correlative factors of hyperuricemia and metabolic syndrome (MS) and study the role of uric acid (UA) in the development of MS. Methods; Data of 12 249 persons undergoing health examination were collected. The dis-ease history was investigated,the biochemical indices were detected,and the general physical data were measured. Multiple stepwise by multivariate Logistic regression model were used to analysis the relationship between UA and MS,at the same time,age,sex,low density lipoprotein cholesterol,total cholesterol were adjusted,the relationship of UA and other factors related to metabolism was also analyzed. Results; Age,BMI,blood pressure,lipids,glucose and UA were higher in MS group than those in non MS group(P < 0.01). The UA level was higher in men than that in women, and increased with accompany the costitution of MS. This phenomenon was obvi-ously in woman. The UA level was increased in man under different glucose levels. Similarly,the UA level was related to the abnor-mal lipid metabolism,but not related to ages. After adjusting age,sex,total cholesterol,low density lipoprotein cholesterol,the rate of MS were higher in the hyperuricemia group when the UA was analyzed as continuous variable,but when uricemia was divided into two groups,the rate of MS in hyperuricemia group was 1.197 times of that in no hyperuricemia group,but non significant difference was found between them. When uricemia was divided into four groups,there were no differences among them. Conclusion; Age, BMI.lipids,glucose,uricemia were the risk factors of MS.hyperuricemia was found in MS group,and hyperuricemia group has higher rate of MS than the non hyperuricemia group,but no direct relationship between MS and hyperurcemia was found when the uricemia was divided into two groups or four groups关键词
高尿酸血症/代谢综合征/相关因素/关联性Key words
hyperuricemia/metabolic syndrome/relevant factors/relationship分类
医药卫生引用本文复制引用
马建峰,闵捷,杜新丽,辛婧,张日华,刘云..尿酸水平与代谢综合征多因素的相关性研究[J].南京医科大学学报（自然科学版）,2011,31(11):1614-1619,6.基金项目
国家自然科学基金(81070684),江苏省"六大人才高峰"项目(2009027),南京医科大学第一附属医院创新团队工程 （81070684）
