南京医科大学学报（自然科学版）2011，Vol.31Issue(12)：1768-1771,4.
神经元型一氧化氮合酶对氟西汀抗抑郁样作用的影响
Effects of neuronal nitric oxide synthase on antidepressant-like effect of fluoxetine
摘要
Abstract
Objective: To explore the relationship between neuronal nitrie oxide synthase (nNOS) molecule and antidepressant-like effects of fluoxetine. Methods;The antidepressant activity was assessed in forced swimming test (FST) and tail suspension test (TST) behavioral paradigm. Total immobility time was registered during the period of 5 or 6 min. ICR mice were treated with fluoxetine or pretreated with L-arginine/Z)-arginine, and wildtype(WT) mice and mice lacking nNOS gene [knock-out (KO)]were treated with flu oxetine, and then the immobility time in the FST and TST was analyzed. Results: In ICR mice,the immobility time in the FST and TST as reduced by fluoxetine treatment, and the antidepressant-like effect of fluoxetine in the FST and TST was prevented by the pre treatment with L-arginine,but not Z>-arginine. In WT mice,administrations of fluoxetine caused antidepressant-like effect in the FST, whereas in KO mice fluoxetine was ineffective. Conclusion: nNOS molecule is required by antidepressant-like effect of fluoxetine.关键词
氟西汀/神经元型一氧化氮合酶/L-精氨酸/nNOS-/-小鼠/抗抑郁样作用Key words
fluoxetine/neuronal nitric oxide synthase/L-arginine,nNOS-/- mice/antidepressant-like effect分类
医药卫生引用本文复制引用
黄新艳,谢娟,许银燕,王俐..神经元型一氧化氮合酶对氟西汀抗抑郁样作用的影响[J].南京医科大学学报（自然科学版）,2011,31(12):1768-1771,4.基金项目
南京医科大学科技发展基金重点项目(2010NJMUZ18) （2010NJMUZ18）
