南京医科大学学报（自然科学版）2012，Vol.32Issue(2)：168-171,4.
半乳糖配体介导多烯紫杉醇脂质体靶向性研究
A targetability study of docetaxel liposomes mediated with galactose ligand
摘要
Abstract
Objective; To study the tissue distribution of docetaxel liposomes modified with galactose ligand (Gal-DOC-L) in mice after intravenous injection,and to discuss the liver targeted effects of Gal-DOC-L. Methods; The determination of drug tissue distribution in mice was measured by HPLC,relative uptake rate (re),peak concentration ratio (Ce) and targeting efficiency (te) were used as the evaluation parameters to evaluate the DOC-L,Gal-DOC-L's liver targeted effect. Results; The relative uptake rates of DOC-L and Gal-DOC-L were 2.80 and 4.34,peak concentration ratios of DOC-L and Gal-DOC-L were 1.67 and 2.38,targeting efficiency percentages of DOC-L and Gal-DOC-L were 28.44% and 38.91%. Conclusion; The drug encapsulated by liposomes has a certain effect of targetability,and liposomes modified with galactose ligand-targeted could further improve the hepatic targeted effect.关键词
多烯紫杉醇/脂质体/半乳糖配体/靶向给药Key words
docetaxel/liposomes/asialoglycoprotein receptor/targeted drug delivery分类
医药卫生引用本文复制引用
吴卫,程怡,吴琼..半乳糖配体介导多烯紫杉醇脂质体靶向性研究[J].南京医科大学学报（自然科学版）,2012,32(2):168-171,4.基金项目
国家自然科学基金资助项目(30772790) （30772790）
