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小花棘豆对小白鼠的毒性试验

杨海东 韩敏 亢和平 邱玉昆 刘上飞 冯陈晨 盛璐丝 李雪蕾

畜牧与饲料科学Issue(11):1-2,2.
畜牧与饲料科学Issue(11):1-2,2.

小花棘豆对小白鼠的毒性试验

Toxicity Test of Oxytropis glabra DC to Mice

杨海东 1韩敏 1亢和平 1邱玉昆 1刘上飞 1冯陈晨 1盛璐丝 1李雪蕾1

作者信息

  • 1. 内蒙古农业大学兽医学院农业部动物疾病临床诊疗技术重点实验室,内蒙古呼和浩特010018
  • 折叠

摘要

Abstract

60 Kunming mice were randomly divided into 5 test groups (A, B, C, D, E)with different doses of Oxytropis glabra DC (60%, 40% ,20%, 10% ,5% )and a control group. The toxicity test of O. glabra was carried out for 60 days. The results showed that mice that were fed with the diet with adding 20% O. globra all survived within 60 days. And mice in the group of adding 40% O. glabra began to die after 57 days. And mice in the group of adding 60% O. glabra began to die after 45 days. The weight gain rate of mice obviously decreased with the increasing of O. glabra in the diet. The final weight of mice in A, B, C test groups was extremely significantly different with control group (P〈0.01 ). And the weight gain of mice in D test group was significantly different with control group (P〈0.05) and that in E group had no significant difference with control group. Compared with control group ,the viscera coefficients (heart, spleen, brain and lung) of mice in different dose groups changed little. The liver coefficient and kidney coefficient increased with the increasing of the dose of O. glabra. The higher the content of O. glabra in the diet was, the more seriously mice's liver and kidney were swollen. And the differences of mice's liver and kidney between A, B, C groups and control group was extremely significant (P〈0.01), which O. gla/bra would caused the injury to the liver and kidney when the dose of O. glabra reached 20%.

关键词

小花棘豆/毒性试验/脏器系数

Key words

Oxytropis glabra DC/toxicity test/viscera coefficient

分类

农业科技

引用本文复制引用

杨海东,韩敏,亢和平,邱玉昆,刘上飞,冯陈晨,盛璐丝,李雪蕾..小花棘豆对小白鼠的毒性试验[J].畜牧与饲料科学,2011,(11):1-2,2.

基金项目

内蒙古农业大学学生科技创新基金项目:内蒙古自治区高等学校科学研究项目(NJ10063). ()

畜牧与饲料科学

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