畜牧与饲料科学Issue(11)：43-45,3.
DNA甲基化与肿瘤研究进展
Advance in DNA Methylation and Tumor
摘要
Abstract
With the development of tumor research, it is found that of epigenetic alterations are also closely related with the development and progression of tumors besides gene mutations. The change of tumor epigenetic inheritance are mainly presented as the aberrant methylation of DNA. The aberrant methylation of DNA occurs in almost all kinds of human tumors, including cutaneous malignancies. DNA methylation refers to the process that under the effect of DNA methylase, methyl is transferred onto a special basic group with S- adenosine-L-methionine （SAM）as the methyl donor. The normal function of gene not only depends on a normal structure, but also depends on a normal state of methylation. The aberrant methylation of DNA takes an important part in the occurrence of tumor.关键词
DNA甲基化/肿瘤/CpG岛/基因表达Key words
DNA methylation/tumor/CpG island/gene expression分类
医药卫生引用本文复制引用
王琳,刘辰,徐江..DNA甲基化与肿瘤研究进展[J].畜牧与饲料科学,2011,(11):43-45,3.基金项目
国家自然科学基金（30371034）资助. （）
