农药学学报2011，Vol.13Issue(6)：576-580,5.DOI:10.3969/j.issn.1008-7303.2011.06.03
1-甲基-3-二氟甲基吡唑酰胺类化合物的合成及抑菌活性
Study on synthesis and antifungal activity of 1-methyl-3-difluoromethyl pyrazolamide derivatives
张琨 1宋成荣 1廖国辉 1杨新娟 1周文明1
作者信息
- 1. 西北农林科技大学理学院,陕西杨凌712100
- 折叠
摘要
Abstract
Fourteen novel pyrazol-4-amide derivatives were synthesized from 3-difluoromethyl-l-methyl-Lh-pyrazole-4-carboxylic acid by the reaction of 3-difluoromethyl-l-methyl-Lh-pyrazole-4-carbonyl chloride with various amines. The structures of these compounds were confirmed by 1H NMR, MS,and IR. Antifungal activity test indicated that all of the synthesized compounds (6a -6g,7a -7g) showed different inhibition on tested plant pathogenic fungi at the concentration of 100 mg/L. The compounds 7a -7g exhibited good antifungal activity, and the growth inhibition rate of compounds 7a, 7d,7g against Glomerella cingulata was above 90%.关键词
吡唑/酰胺/合成/抑菌活性Key words
pyrazole/synthesis/amide/antifungal activity分类
化学化工引用本文复制引用
张琨,宋成荣,廖国辉,杨新娟,周文明..1-甲基-3-二氟甲基吡唑酰胺类化合物的合成及抑菌活性[J].农药学学报,2011,13(6):576-580,5.
