摘要
Abstract
Objective To investigate the effects of Huaiqihuang granule on treatment, immune regulation and its side effect of pediatric primary nephrotic syndrome by the contrast research of Huaiqihuang granule puls glucocorticoid and glucocorti-coid only. Methods 40 children with primary nephrotic syndrome were randomly tow groups. The treatment group(20 children) were teated with Huaiqihuang granule puls glucocorticoid, the contrast group (20 children) had glucocorticoid only. The follow were obseved; the time of edema regression and prourine normal, the infected numbers and the change of cellular immunity ( CD3, CD4,CD8,CD4/CD8) and humoral immunity(IgA,IgM,IgG) before and after treatment. Observation period was twelve weeks. Results In the treatment group, the time of edema regression and prourine normal was shorter than that in the contrast group(P < 0. 05) , and the incidence rate of infection was lesser than in the contrast group (P < 0. 05 ). The levels of IgG, CD3 and CD4/CD8 were significantly increase in the treatment group, the levels of IgA and IgM had increase trend, but had no Statistically significant difference in two group(P >0. 05). Tow groups had nausea, vomit,Diarrhea,no rash and the abnormal of liver and kidney function, there were no Statistically significant difference. Conclusion The adjuvant treatment of Huaiqihuang granule on primary nephrotic syndrome can shorten the time of edema regression and prourine normal, enhance the immulogical regulation function, and decrease the chance of infection. Also the adjuvant treatment of Huaiqihuang granule enhance the curative effect of glucocorticoid and improve prognosis of the disease. There is no side effect in the process,which confirm that Huaiqihuang granule is safety and effective adjuvant drug of primary nephrotic syndrome.关键词
肾病综合征/槐杞黄颗粒/体液免疫/细胞免疫/儿童Key words
nephrotic syndrome/Huaiqihuang granule/humoral immunity/cellular immunity/children分类
医药卫生
