四川医学2011，Vol.32Issue(12)：1879-1882,4.
聚乙二醇化重组人粒细胞集落刺激因子预防化疗后中性粒细胞减少的临床观察
Clinical observation of pegylated recombinant human granulocyte colony-stimulating factor in prevention chemotherapy-induced neutropenia
兰海涛 1罗树春 1胡洪林 1吴琦1
作者信息
- 1. 四川省人民医院肿瘤科,四川成都610072
- 折叠
摘要
Abstract
Objective To compare the efficacy and safety of daily injection of recombinant human granulocyte colony-stimulating factor (rhG-CSF) and a single subcutaneous injection of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in chemotherapy-induced neutropenia. Methods In the present randomized, match and cross-over study, enrolled 42 patients with previously untreated cancer and with normal bone marrow function were randomly divided into 2 matched groups. Each patient received two cycles of chemotherapy of identical regimen. In the study cycle, the patients received a single subcutaneous injection of PEG-rhG-CSF 100 u,g/kg; and in control cycle, daily subcutaneous infection of rhG-CSF 5 u,g/kg/d and continued for 7 days or until the absolute neutrophil count ( ANC) became 3s5. 0 x 109/L . Results The rates of ANC <2. 0 X 109/L in the 40 evaluable study cycles and 44 evaluable control cycles were 30.00% and 31. 8% with the duration of (3 ± 1. 155) d and (4 ±1.225 )d respectively. The safety profiles of the PEG-rhG-CSF and rhG-CSF groups were similar. Conclusion A single subcutaneous injection of PEG-rhG-CSF 100 (xg/kg provides neutrophil support and a safety profile comparable to regimen of daily subcutaneous injection of rhG-CSF 5u^/(kg ? D) in patients receiving a variety of myelosuppressive chemotherapy regimens.关键词
粒细胞集落刺激因子/聚乙二醇化/化疗/中性粒细胞减少Key words
granulocyte colony-stimulating factor/ pegylation/ chemotherapy/ neutropenia.分类
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兰海涛,罗树春,胡洪林,吴琦..聚乙二醇化重组人粒细胞集落刺激因子预防化疗后中性粒细胞减少的临床观察[J].四川医学,2011,32(12):1879-1882,4.
