四川医学2011，Vol.32Issue(12)：1884-1886,3.
重组人白介素-11治疗鼻咽癌同步放化疗相关性口腔粘膜炎的疗效观察
Efficacy observation of recombinant human interleukin-11 in oral mucositis related with nasopharyngeal cancer radiochemotherapy
摘要
Abstract
Objective To observe the efficacy of recombinant human interleukin-11 (IL-11) in treatment of oral mucosi-tis related with nasopharyngeal carcinoma radiochemotherapy. Methods 60 patients of nasopharyngeal carcinoma with pathologically confirmed were randomly divided into two groups: 30 patients in observation group (IL-11 gargle plus conventional therapy) and 30 cases in control group (conventional treatment). Results The total effective rate was 83. 3% in observation group, while the control group was 60. 0% , there was statistically significant in both groups( j￡ = 4. 0219 ,P=0. 0449). Further analysis found that there was not statistically significant for II degree of efficacy of oral mucositis in two groups(F = 19, P = 0. 2263). But in grade M , showed statistical significance was observed both the observation group and control group(F = 6, P=0. 0500). In pain control, the two groups was statistically significant (j￡ = 4. 0219, P = 0. 0449) , the pain relief was significantly higher in the observation group. Conclusion Recombinant human interleukin-11 was effective and low toxicity in treatment of acute radiation mucositis and can significantly improve patient's quality of life. It is beneficial to the successful completion of radiochemotherapy and have important clinical value.关键词
重组人白介素-11/鼻咽癌/口腔粘膜炎Key words
recombinant interleukin-11/nasopharyngeal carcinoma/oral mucositis分类
医药卫生引用本文复制引用
胡建萍,任涛,杜国波,高茜..重组人白介素-11治疗鼻咽癌同步放化疗相关性口腔粘膜炎的疗效观察[J].四川医学,2011,32(12):1884-1886,3.基金项目
南充市科技局项目(编号:2010SF20) （编号:2010SF20）
