山东医药2011，Vol.51Issue(46)：9-10,2.
RCCC组织中肺癌肿瘤抑制因子1的表达变化及意义
Expression and significance of TSLC1 in human renal clear cell carcinoma
摘要
Abstract
Objective To detect the expression of tumor suppressor in lung cancer 1 (TSLC1) in tissues of normal human kidney and renal clear cell carcinoma ( RCCC) and explore its clinical significance. Methods The expression of TSLC1 in 40 RCCC samples and 18 pericancerous normal renal tissues were examined by immunohistochemistry SP method. Results The positive expression rate of TSLC1 in RCCC (20% ) was significantly lower than that in nearby non-tumorous tissues ( 100 % , P<0.01 ) , the positive expression of TSLC1 in RCCC with lymph node metastasis was significantly lower than that in RCCC without lymph node metastasis ( P <0.01 ). The expression of TSCL1 was significantly associated with tumor clinical stage and grade, the higher the clinical stage and grade, the lower the rate of positive expression of TSCL1 (r = - 0.300, - 0.404, all P < 0.05). Conclusions There is significant loss of expression of TSCL1 in RCCC tissues; the expression of TSLC1 showes a negative correlation with the pathological stage and grade of RCCC, the loss of expression of TSCL1 may be related to the occurrence and development of RCCC.关键词
肾肿瘤/肾透明细胞癌/肺癌肿瘤抑制因子1Key words
renal neoplasms/ renal clear cell carcinoma/ tumor suppressor in lung caneerl分类
医药卫生引用本文复制引用
李鸿文,彭云滔,于兰,宋铁山..RCCC组织中肺癌肿瘤抑制因子1的表达变化及意义[J].山东医药,2011,51(46):9-10,2.
