山东医药2011，Vol.51Issue(46)：11-13,3.
膀胱移行细胞癌组织中NF-κB p65、uPA、Bcl-2的表达变化及其意义
Expression and significance of NF-κB p65, uPA, Bcl-2 in transitional cell carcinoma of bladder
摘要
Abstract
Objective To observe the expression of NF-κB p65, uPA and Bcl-2 in bladder transitional cell carcinoma (here in after referred to as bladder cancer) tissue, and explore its relevance. Methods The expression of NF-κB p65, uPA and Bcl-2 in 40 cases of bladder cancer and 10 cases of normal bladder tissue were detected by immunohistochemical technique, its relationships with pathological grade, clinical stage, invasion, metastasis, recurrence and the correlation of NF-kB p65 and uPA, Bcl-2 were analized. Results The expression of NF-kB p65, uPA, Bcl-2 in bladder cancer were significantly higher than that of normal bladder tissue (P <0.05); expression of NF-kB p65 and uPA in bladder cancer has relation to pathological grade, clinical stage, lymph node metastasis (all P <0. 05), expression of Bcl-2 has relation to pathological grade, clinical stage (P<0.05), but not to lymph node metastasis(P >0.05). The expression of NF-kB p65 and uPA, Bcl-2 in bladder cancer was positively correlated( r = 0.388, 0.462, all P <0.05). Conclusions NF-κB p65, uPA and Bcl-2 in bladder cancer with high expression and have relation to clinicopathological characteristics of the bladder cancer. NF-kB p65 may promote the progress of bladder cancer by regulating uPA, Bcl-2. NF-κB p65, uPA and Bcl-2 can be used as biomarkers to decide transitional cell carcinoma of bladder invasion, metastasis and prognosis.关键词
膀胱肿瘤/膀胱移行细胞癌/核因子-κB p65/尿激酶型纤溶酶原激活物/Bcl-2蛋白Key words
bladder tumor/transitional cell carcinoma of bladder/nuclear factor kappaB p65/ urokinase plasminogen activator/ Bcl-2分类
医药卫生引用本文复制引用
胡映秋,鲁雄兵,李里香,朱安义,林双泉,洪正东,史子敏..膀胱移行细胞癌组织中NF-κB p65、uPA、Bcl-2的表达变化及其意义[J].山东医药,2011,51(46):11-13,3.基金项目
江西省教育厅科学技术研究项目(GJJ09109). （GJJ09109）
