山东医药2011，Vol.51Issue(47)：9-11,3.
雌激素联合甘草酸对去卵巢小鼠骨代谢及生物力学指标的影响
Effects of combination of estrogen and glycyrrhizic acid on bone metabolism and biomechanic in ovariectomized mice
摘要
Abstract
Objective To investigate the effects of combination of estrogen and glycyrrhizic acid( GA) on bone metab-olism and biomechanic in ovariectomized mice. Methods Sixty female mice were randomly divided into six groups, all mice were subjected to bilateral ovariectomy except sham operation group, then mice showed no abnormal behavior were ad-ministrated intragastrically with drugs 4 d after . The ovariectomized group was given vehicle, the estrogen group was given estrogen of 32 μg/( kg·d) , the low dose of GA (LGA) group was given GA of 50 μg/( kg·d), the high dose of GA (HGA) group was given GA of 100 μg/(kg · d),the combination ( ELGA)group was given estrogen of 32 μg/(kg · d) and GA of 50 μg/(kg · d). After 45 days, the viscera index, the content of serum Ca2+ , ALP and bone hydroxyproline (Hyp), biomechanical properties of bone( femur and lumbar) were measured. Results The ovary index in LGA group was significantly lower than that in sham-operation group and estrogen group, and the bone Hyp was higher than that in ovariec-tomized group; the maximum load of the fourth vertebra in the HGA group was significantly lower than that in estrogen group; the ovary index and the maximum load of the fourth vertebra in the ELGA group were significantly higher than those in ovariectomized group, and the maximum load of the fourth vertebra was significantly higher than that in sham-operation group; the ovary index in ovariectomized group was lower than that in sham-operation group, the ovary index and thymus in-dex were lower than those in estrogen group; the ovary index and the maximum load of the fourth vertebra in estrogen group were higher than those in ovariectomized group, the later index was higher than that in sham-operation group, P<0.05 or 0.01. Conclusions Both GA single use and its estrogen combination therapy have preventive effect in osteoporosis.关键词
雌激素/甘草酸/骨质疏松/骨代谢/骨生物力学Key words
estrogen/glycyrrhizic acid/ osteoporosis/ bone metabolism/ biomechanical properties分类
医药卫生引用本文复制引用
曾晓东,欧定强,刘月红,李慧敏,方少强,杨阳,汪靖涛,崔燎,刘钰瑜..雌激素联合甘草酸对去卵巢小鼠骨代谢及生物力学指标的影响[J].山东医药,2011,51(47):9-11,3.基金项目
国家自然科学基金资助项目(81102450) （81102450）
广东省大学生创新实验基金资助项目(4404310005). （4404310005）
