山东医药2011，Vol.51Issue(47)：18-20,3.
浸润性乳腺癌组织中14-3-3σ、p73α蛋白表达及临床意义
Expression and clinical significance of 14-3-3σ, p73α protein in infiltrating breast cancer
摘要
Abstract
Objective To investigate the effects of 14-3-3σ and p73α protein expression in the occurrence and devel-opment of infiltrating breast cancer. Methods The expression of 14-3-3cr and p73α protein were measured in 94 infiltra-ting breast cancers tissues (invasive carcinoma group), 15 intraductal carcinoma in situ (carcinoma in situ group), 1S un-typical ductal epithelial hyperplasia (untypical hyperplasia group), 15 intraductal papilloma (papilloma group) , 20 hyper-plastic disease of the breast (hyperplastic group) and 10 peficancerous tissues ( peficancerous tissues group) which resected in our hospital by immunohistochemistry PV two-step method, analyzed the correlation of both indexes and which between clinical pathologic features. Results The positive rate of 14-3-3σ protein in invasive carcinoma group was significantly lower than that in the other groups, and the positive rate of p73α protein was significantly higher (all P < 0.05 ). The ex-pression of 14-3-3σ protein was significantly correlated with histological grade, TNM stage, axillary lymph node metastasis and HER-2 expression, the expression of p73α protein was significantly correlated with axillary lymph node metastasis, his-tological grade,TNM stage, ER and PR expression. And there were negative correlations between the expression of 14-3-3σ and p73α protein. Conclusion The protein of 14-3-3σ and p73α may be related to the development of infiltrating breast cancer, and combined detection of which may provide reference for early diagnosis and treatment of breast cancer.关键词
乳腺癌,乳腺肿瘤/14-3-3σ蛋白/p73α蛋白/免疫组织化学Key words
breast tumor, breast cancer/ 14-3-3 sigma/ p73 alpha/ immunohistochemisty分类
医药卫生引用本文复制引用
姚萍,刘廷,赵树鹏,高源,齐凤杰..浸润性乳腺癌组织中14-3-3σ、p73α蛋白表达及临床意义[J].山东医药,2011,51(47):18-20,3.基金项目
辽宁省科学技术计划项目(2010225034). （2010225034）
