山东医药2011，Vol.51Issue(49)：1-3,3.
慢性阻塞性肺疾病患者ADAM33基因单核苷酸多态性的研究
Association between ADAM33 gene polymorphism and COPD
摘要
Abstract
Objective To investigate the association between the polymorphism of S2 locus allele in ADAM33 gene and COPD. Methods Allele-speeific polymerase chain reaction (AS-PCR) and DNA sequencing were used to determine the polymorphism of S2 locus allele in ADAM33 gene in 112 patients with COPD and 105 healthy controls. Results The genotype distributions of S2 locus allele in ADAM33 gene in case group and control group did not deviate from Hardy-Wein berg equilibrium. The frequencies of the genotypes (CC, CG, GG) were 54.5% , 34.8% and 10.7% ; in the 112 COPD patients and 69.5% , 26.7% and 3. 8% in the 105 controls, respectively, showing a significant difference in the distribu tion of the genotypes (CC,CG,GG) between COPD patients and healthy controls (x2 =6.662, P<0.05). The frequen cies of the alleles (C,G) were 0.719 and 0.281 in the COPD patients and 0.829 and 0. 171 in the controls, respectively, also showing a significant difference in the allele frequency between them (x2 =7.424, P <0.05). Conclusion The pol ymorphism of S2 locus allele in ADAM33 gene is associated with the susceptibility to COPD.关键词
肺疾病,慢性阻塞性/ADAM33/多态性,单核苷酸/聚合酶链反应Key words
pulmonary disease, chronic obstructive/ ADAM33/ polymorphism, single nudeotide/ polymerase chain reaction分类
医药卫生引用本文复制引用
迟翔宇,肖伟,王建平,姜洪娟,王来城,王静..慢性阻塞性肺疾病患者ADAM33基因单核苷酸多态性的研究[J].山东医药,2011,51(49):1-3,3.基金项目
山东省卫生厅资助项目(2007 BZZ02). （2007 BZZ02）
