山东医药2011，Vol.51Issue(50)：4-6,3.
胃癌组织中E-cadherin基因启动子异常甲基化状态观察
Aberrant methylation of E-cadherin gene promoter in gastric carcinoma
摘要
Abstract
Objective To observe the aberrant methylation of E-cadherin gene promoter in gastric carcinoma. Methods Aberrant methylation of E-cadherin gene promoter was examined by methylation specific-PCR (MSP) in gastric carcinoma and normal gastric tissues (n =54). Results Aberrant methylation rate of E-cadherin gene promoter was 48. 1% (26/54) in gastric carcinoma tissues and and 11. 11 % (6/54) in normal gastric tissues respectively (P < 0.05). There were significant correlation between E-cadherin gene promoter methylation rate and pathology type, clinical staging, depth of tumour invasion and lymphatic metastasis. Conclusion Methylation of E-cadherin is a common molecular event and may be related to invasion and metastasis of gastric carcinoma.关键词
胃肿瘤/钙黏蛋白/甲基化Key words
gastric carcinoma/ E-cadherin/ methylation分类
医药卫生引用本文复制引用
姜蕊,赵春明,宋美娟,宋伟..胃癌组织中E-cadherin基因启动子异常甲基化状态观察[J].山东医药,2011,51(50):4-6,3.基金项目
山东省自然科学基金资助项目(Z2007C18) （Z2007C18）
山东省科技攻关项目(2007GG30002024). （2007GG30002024）
