实验动物与比较医学2011，Vol.31Issue(6)：422-425,4.DOI:10.3969/j.issn.1674-5817.2011.06.005
低氧训练对大鼠血液内促红细胞生成素、血红蛋白和红细胞水平的影响
Effects of Hypoxic Training on Blood EPO, Hb and RBC Level in Rats
摘要
Abstract
Objective To investigate effects of 7 day hypoxic training on the level of Erythropoietin (EPO), hemoglobin(Hb) and red blood cell (RBC) in blood of SD rats, and to obtain the experimental evidence of adaptation to hypoxic training in rats. Methods The rats were exposed in different concentration of hypoxic environment for 2h/day, the time of treadmill running of rats is 30min/day. The level of EPO was checked by ELISA, and the level of RBC and Hb were measured by automatic blood cell analyzer. Results (1) No effects of hypoxic exposure in 15% O2 and 11% O2 environment on EPO level were found significantly, but treadmill running in 15% O2 environment enhance EPO level in blood of rats. (2) The number of RBC was increased significantly in rats which exercised on treadmill or stayed in 15% O2or 11% O2 environment. (3) The increase of concentration of Hb was found significantly in rats which stayed in 15% O2or 11% O2 environment. (4) Effects of hypoxic training on RBC and Hb level disappear in rats 15days after hypoxic training. Conclusion Production of RBC and Hb are signifi cantly induced by hypoxic training in rats, but lasting time of enhancing effect is shorter than 15 days.关键词
低氧/促红细胞生成素/血红蛋白/红细胞/大鼠Key words
Hypoxia/ Erythropoietin/ Hemoglobin/ Red blood cells/ Rats分类
生物科学引用本文复制引用
娄淑杰,焦颖..低氧训练对大鼠血液内促红细胞生成素、血红蛋白和红细胞水平的影响[J].实验动物与比较医学,2011,31(6):422-425,4.基金项目
国家自然科学基金(30870349)、上海市教委科研创新项目(09yz304)和上海市重点学科建设项目(S30802)共同资助. （30870349）
