实验动物与比较医学2012，Vol.32Issue(1)：17-19,22,4.DOI:10.3969/j.issn.1674-5817.2012.01.004
小鼠三种急性胃溃疡模型的比较
Comparison on Three Kind Models of Acute Gastric Ulcer in Mice
摘要
Abstract
Objective To compare three models of acute gastric ulcer in mouse, and describe the modeling method and some related notes. Method Three kinds of mice ulcer models induced by binding and water immersion-restraint stress, ethanol and reserpine respectively under different conditions; the extent of gastric mucosal injury was evaluated grossly and histologically. Results Three models all are able to form a stress ulcer, which are mainly appeared superficial. The water immersion-restraint stress method in 21±1°C with 15 h and the ethanol method in 0.2 ml or 0.1 ml per mouse both have effects, while both have a low modeling death rate. Conclusion The Ethanol method is the best for modeling of acute gastric ulcer in mouse.关键词
水浸法/利血平法/乙醇法/急性胃溃疡Key words
Water immersion-restraint stress/ Reserpine method/ Ethanol method/ Acute gastric ulcer分类
生物科学引用本文复制引用
王慧,周星,张一云,卓书洪..小鼠三种急性胃溃疡模型的比较[J].实验动物与比较医学,2012,32(1):17-19,22,4.基金项目
2010年度海南省自然科学基金(批准号:30834) （批准号:30834）
