生物加工过程2011，Vol.9Issue(6)：45-48,4.DOI:10.3969/j.issn.1672-3678.2011.06.010
野生地参多糖对四氧嘧啶致糖尿病小鼠血糖和血脂的影响
Hypoglycemic and hypolipidemic effect of polysaccharide from wild plant Lycopus lucidus Turcz.on alloxan-induced diabetic mice
摘要
Abstract
The effect of polysaccharides from wild plant Lycopus lucidus Turcz. On hypoglycemia and hypo-lipidemia in alloxan-induced mice was investigated. The diabetic model mice were established by intra-ab-dominal injection of alloxan. Then, the living diabetic mice were divided into six groups. Three groups were treated with 100, 200 and 400 mg/(kg·d) polysaccharide from L. Lucidus Turcz., respectively by ig administration, and one group given phenfomide 100 mg/ ( kg · d) by ig adminstration as the positive control ,and another group was given normal saline as the diabetic model control. The normal control group was tested on the normal mice by ig saline. After 14 days of treatment, the blood glucose and the serum lipid content of each group were detected. The results indicated that polysaccharide from L. Lucidus Turcz. Has no hyperglycemia effect on normal mice. Compared with the diabetic model control group, 100,200 and 400 mg/(kg·d) polysaccharide from L. Lucidus Turcz could decrease the blood glucose in diabetic mice(P < 0.01). Meanwhile, the results also showed that polysaccharide from L. Lucidus Turcz. Could decrease thelevel of serum TC, TG and LDL-C in diabetic mice. In addition,200 and 400 mg/(kg·d) polysaccharide from L. Lucidus Turcz. Could increase the serum contents of HDL-C in the mice (P < 0.05), but 100 mg/(kg·d) polysaccharide from L. Lucidus Turcz. Had no effects on serum HDL-C in diabetic mice (P > 0. 05). Polysaccharide from L. Lucidus Turcz. Had significant effects on hypoglycemic and hypolipidemic action in diabetic mice induced by alloxan.关键词
四氧嘧啶/降血糖/降血脂/地参/多糖Key words
alloxan/hypoglycemic effect/hypolipidemic effect/Lycopus lucidus Turcz/polysaccharide分类
医药卫生引用本文复制引用
熊伟,陈贵元,谭德勇,左绍远..野生地参多糖对四氧嘧啶致糖尿病小鼠血糖和血脂的影响[J].生物加工过程,2011,9(6):45-48,4.基金项目
大理学院青年科学基金资助项目(2007X26) （2007X26）
