陕西师范大学学报：自然科学版2011，Vol.39Issue(6)：72-75,80,5.
FAK表达水平对人肝癌细胞运动、增殖、凋亡等的影响
Effect of FAK expression level on the motility, proliferation and apoptosis of SMMC—7721 cells
摘要
Abstract
The siRNAs targeting FAK were designed and transfected into SMMC—7721 cells using a calcium phosphate transfection method.The changes of FAK expression level were detected with RT-PCR and western blot.The effects of FAK gene knockdown on migration,proliferation and apoptosis were investigated.The results show that FAK mRNA and protein level were significantly regulated down post the cells transfection by FAK siRNA.The proliferation and migration of SMMC—7721 cells were significantly inhibited,and the apoptosis of transfected cells were significantly enhanced.The results above indicate that the specific FAK siRNA can inhibits the motility and proliferation of SMMC—7721 cells.关键词
粘膜斑激酶/RNAi/肝癌/细胞运动/细胞增殖和凋亡Key words
focal adhesion kinase（FAK）/RNAi/hepatocarcinoma/cell motility/cell proliferation and apoptosis分类
医药卫生引用本文复制引用
张楠楠,魏丽丽,强荣兵,聂红娟,高晓杰,侯颖春..FAK表达水平对人肝癌细胞运动、增殖、凋亡等的影响[J].陕西师范大学学报：自然科学版,2011,39(6):72-75,80,5.基金项目
陕西省自然科学基础研究计划项目 （）
西安市科技局社会发展研发项目 （）
