山西医科大学学报2012，Vol.43Issue(2)：148-149,2.DOI:10.3969/J.ISSN.1007-6611.2012.02.022
大鼠缺血性心律失常模型制备方法的改进
Improvement of the method in preparation of ischemic arrhythmia rat model
纪影实 1邵江波 1关凤英 1陈立1
作者信息
- 1. 吉林大学白求恩医学院药理学系,长春,130021
- 折叠
摘要
Abstract
Objective To explore a better method of inducing the ischemic arrhythmia rat model to increase the successful rate. Methods The ischemic arrhythmia rat models were established by ligating the left anterior descending coronary artery with thead( traditional method ) and fixing the left anterior descending coronary artery with the silica gel tube( silica gel tube method ), respectively. The successful rate, the type, the duration and the grade of the cardiac arrhythmia were observed and compared. Results Compared with traditional method, the successful rate and the cardiac arrhythmia grade were increased significantly( P <0. 05 ) ,and the duration of cardiac arrhythmia was prolonged obviously by silica gel tube method( P <0.05 ). Conclusion The silica gel tube method of producing ischemic arrhythmia in rats should be widely used in the experiment teaching because of its high achievement ratio and its easiness to operate.关键词
缺血性心律失常/硅胶管法/实验教学Key words
ischemic arrhythmia/ silica gel tube method/ experiment teaching分类
医药卫生引用本文复制引用
纪影实,邵江波,关凤英,陈立..大鼠缺血性心律失常模型制备方法的改进[J].山西医科大学学报,2012,43(2):148-149,2.
