陕西医学杂志2012，Vol.41Issue(2)：223-225,3.
丁丙诺啡超前镇痛对围术期应激反应和术后自控镇痛的影响
Preemptive analgesia effects of buprenorphine on stress responses and postoperative pain management
摘要
Abstract
Objective: To study the preemptive analgesia effects of buprenorphine on postoperative pain management and stress responses. Methods: 60 patients underwent spinal surgery were randomly divided into two groups with 30 cases each, patients in group P were administrated with 0. 15mg buprenorphine intravenously 30 min before operation. In group C, patients were administrated with 0. 15mg buprenorphine at the end of operation. All patients received postoperative analgesia with patient controlled intravenously analgesia(PCIA). The analgesic effect was evaluated by VAS score at 2,6,12,24 and 48 h after operation. The concentration of Cor and CRP in serum a-head of anesthesia induction (TO) and at 6h (Tl) , 12h (T2) after operation was measured. Results: VAS scores of group P were significantly lower than those in group C at the different time point (P<0. 05). The concentrations of Cor and CRP in two groups were significantly increased at Tl, T2, respectively, as compared with values at TO. Compared to group C, the concentrations of Cor and CRP were significantly lower at Tl and T2 than those in group P (P<0. 05). Conclusion;Preemptive analgesia with buprenorphine can more effectively inhibit perioperatively stress responses and have effective postoperative analgesia.关键词
镇痛/应激/丁丙诺啡Key words
Analgesia/Stress/Buprenorphine分类
医药卫生引用本文复制引用
粱琪,金梅生..丁丙诺啡超前镇痛对围术期应激反应和术后自控镇痛的影响[J].陕西医学杂志,2012,41(2):223-225,3.
