摘要
Abstract
Objective:To compare the efficacy and toxicity of neoadjuvant chemotherapy of oxaliplatin (OXA) plus docetaxel( DTX) and cisplatin( DDP) plus docetaxel before radical hysterectomy in patients with stage Ⅰ B2 ~ Ⅱ B locally advanced cervical cancer. Methods: From February 2009 to December 2010, 65 patients with stage Ⅰ B2 - Ⅱ B locally advanced cervical cancer were enrolled in the study. The patients were randomly divided into experimental group (n=35) and control group (n=30). The experimental group received oxaliplatin 130 mg/m2 plus docetaxel 75 mg/m2, while those patients in the control group were given the cisplatin 60 mg/m2 plus docetaxel 75 mg/m2. All of the patients in two groups were given two cycles of neoadjuvant chemotherapy. The efficacy, side effects of neoadjuvant chemotherapy and pathological examination after hysterectomy were compared in two groups. Results:①There was no significant difference in chemotherapy efficacy between the two groups(97.1% vs 96.7%, P>0.05). ②The toxicity of neoadjuvantchemotherapy: the incidence of leucopenia (grade Ⅱ ), neutropenia (grade Ⅱ ) in the experimental group were lower than those in control group (5.7% vs 18. 3% and 15. 7% vs31. 7%,P<0. 05). However, the incidence of alopecia, nausea, vomiting and renal toxicity (grade Ⅰ , Ⅱ) in the experimental group were significantly lower than those in control group(P<0. 05). And the incidence of peripheral nerve toxicity (grade Ⅰ , Ⅱ ) in the experimental group were significantly higher than those in control group (28. 6% vs 6. 7% and 20. 0% vs 0%, P<0. 05). ③There were no significant difference (P>0. 05) between two groups in pathological complete remission rate, ideal pathological response rate ,the cervical stromal invasion, parametrial invasion, positive rate of surgical margins etc( P>0.05). Conclusions;The neoadjuvant chemotherapy of both OXA plus DTX and DDP plus DTX have significant efficacy in the treatment of locally advanced cervical cancer, and the toxicity of OXA plus DTX is lower than DDP plus DTX, the former would be significantly improving quality of life during neoadjuvant chemotherapy.关键词
奥沙利铂/顺铂/局部晚期宫颈癌/新辅助化疗/根治性子宫切除术Key words
Oxaliplatin/ Cisplatin/ Locally advanced cervical cancer/ Neoadjuvant chemotherapy/ Radical hysterectomy分类
医药卫生
