实用妇产科杂志2011，Vol.27Issue(12)：914-917,4.
妊娠时机对妊娠合并系统性红斑狼疮病情及妊娠结局的影响
Influence of Conception Timing on Lupus Flares and Pregnancy Outcomes in Pregnant Women with Systemic Lupus Erythematosus
尹玉竹 1周水生 1吴玲玲 1黄建林 1张培珍1
作者信息
- 1. 中山大学附属第三医院,广东广州510630
- 折叠
摘要
Abstract
Objective:To explore the influence of conception timing on lupus flares and pregnancy outcomes in pregnant women with systemic lupus erythematosus (SLE). Methods:The clinical data of 46 pregnant women with SLE were retrospectively analyzed. According to the different conception timing, 46 gravi-das with SLE were divided into two groups: 32 patients who had controlled SLE and remission duration over 6 months before conception belonged to guidance pregnant group. Active lupus disease before conception and new onset SLE during pregnancy belonged to nonguidance pregnant group (n = 14). The rate of lupus flares and pregnancy outcomes were compared between two groups. Results:①The rate of lupus flare and dosage of prednisone in guidance pregnant group were 15. 6% and 9.6 ±1.1 mg/d, in nonguidance pregnant group was 100% and 24.1 ±18.2 mg/d, which was significant higher (P=0.000,P=0. 012). ② The abnormal rate of 24 hours proteinuria, creatine and anti-dsDNA antibody in guidance pregnant group were significantly lower than that in nonguidance pregnant group (P=0. 003, P=0. 004, P=0. 021). ③There was no maternal or fetal death in guidance pregnant group; whereas 1 maternal death and 5 fetal losses occurred in nonguidance pregnant group. The alive birth rate in guidance pregnant group (100) was significantly higher than that in nonguidance pregnant group (64. 3%) ( P = 0. 001). The incidence of fetal loss and fetal growth retardation in guidance pregnant group was 0 and 18. 8% respectively, in nonguidance pregnant group was 35. 7% and 50. 0% which was obviously higher (P=0. 001, P=0.030). Conclusions: Conception timing for pregnant women with SLE has substantial influence on lupus flares and pregnant outcomes, especially on fetal outcomes. Planning conception in SLE remission duration over 6 months before conception can improve the pregnancy outcome.关键词
妊娠/时机/系统性红斑狼疮/妊娠结局/泼尼松Key words
Conception/ Timing/ Systemic lupus erythematosus/ Pregnancy outcome/ Prednisone分类
医药卫生引用本文复制引用
尹玉竹,周水生,吴玲玲,黄建林,张培珍..妊娠时机对妊娠合并系统性红斑狼疮病情及妊娠结局的影响[J].实用妇产科杂志,2011,27(12):914-917,4.
