实用肝脏病杂志2012，Vol.15Issue(2)：120-122,3.DOI:10.3969/j.issn.1672-5069.2012.02.013
不同HBV基因型感染慢性乙型肝炎患者对核苷(酸)类药物治疗的应答反应比较
Relationship of HBV genotypes to changes of liver biopsies and to responses to antiviral therapy of nucleoside analogs
摘要
Abstract
Objective To investigate the relationship of HBV genotype to liver biopsy and the antiviral therapy of nucleoside analogs. Methods We collected 541 patients with chronic hepatitis B virus infection. The patients were divided into 4 groups at random,e.g. Lamivudine(n=136),telbivudine(n=135),entecavir(n=135)and adefovir (n=135cases). The treatment lasted for 48 weeks. The genotype of HBV were determined by PCR before therapy. We also checked the liver function, HBV DNA and HBV M. Moreover,we performed the liver biopsies in 109 cases. Results The genotype B of HBV was 94 cases(l7.38%),type C was 410 cases(75.79%),the type B/C was 37 cases (6.84%),and no other types of genotype had been detected;in HBV genotype B,G3 in liver tissues accounted for 37.3% and S3 for 13.0%,while in HBV genotype C,G3 accounted for 8.7% and S3 for 22. 7%(P<0.05);in patients treated with lamivudine,telbivudine or entecavir,the efficacy in genotype B was better than patients with genotype C and B/C infection (P<0.05). When we used adefovir therapy, there was no statistical significance (P>0.05)between genotype B and genotype C or B/C infection. Conclusion HBV genotype has close relationship with liver lesions and the antiviral therapy of nucleosides.关键词
慢性乙型肝炎/HBV基因型/肝组织病理学/核苷(酸)类药物Key words
Hepatitis B/ HBV genotypes/ Liver biopsy/ Nucleosides引用本文复制引用
杨丽敏,彭勋,赵艳茹,赵培利,马艳玲,杨方..不同HBV基因型感染慢性乙型肝炎患者对核苷(酸)类药物治疗的应答反应比较[J].实用肝脏病杂志,2012,15(2):120-122,3.基金项目
河北省科学技术研究与发展计划项目(项目编号:10276105D-10) （项目编号:10276105D-10）
