实用肝脏病杂志2012，Vol.15Issue(2)：123-125,3.DOI:10.3969/j.issn.1672-5069.2012.02.014
聚乙二醇干扰素联合利巴韦林治疗慢性丙型肝炎疗效观察
Observation on the efficacy of peginterferon and ribavirin in the treatment of patients with chronic hepatitis C
朱义玲 1陈丽 1赵卫峰 1甘建和1
作者信息
- 1. 215006,江苏省苏州市,苏州大学附属第一医院感染病科
- 折叠
摘要
Abstract
Objective To evaluate the clinical effects of combination of peginterferon and ribavirin in the treatment of patients with chronic hepatitis C. Method 58 patients with chronic hepatitis C received a combination of Pagasys (l80μg/week)and ribavirin (800~1200mg/d)for 48 weeks. Liver function and level of HCV RNA were determined at the 12th,24th and 48th week during the treatment. Result The early virological response (EVR)rates and sustained virological response(SVR)rates in patients with genotype 1 were 57.1% and 53.6%,but in genotype non-1 patients those were 76.7% and 80%, respectively (P<0.05);the early virological responserate in patients with high serum HCV RNA level was 56.3%,much lower than 80.8%(P<0.05)in patients with low serum HCV RNA level. Conclusion The response to the combination treatment in patients with chronic hepatitis C is influenced by genotype and the serum level of HCV RNA.关键词
慢性丙型肝炎/聚乙二醇干扰素/利巴韦林/治疗Key words
Hepatitis C/Peginterferon(α-2a)/Ribavirin/Therapy引用本文复制引用
朱义玲,陈丽,赵卫峰,甘建和..聚乙二醇干扰素联合利巴韦林治疗慢性丙型肝炎疗效观察[J].实用肝脏病杂志,2012,15(2):123-125,3.
