实用医学杂志2011，Vol.27Issue(24)：4385-4387,3.DOI:10.3969/j.issn.1006-5725.2011.24.014
西洛他唑对强噪声所致豚鼠耳蜗血流及听阈偏移的影响
Effects of cilostazol on cochlear blood flow and hearing threshold shift in guinea pigs after noise exposure
摘要
Abstract
Objective To explore the effects of cilostazol, a PDE3A inhibitor, on cochlear blood flow and hearing threshold shift in guinea pigs after being exposed to intense noise. Methods Forty male guinea pigs were randomly divided into four groups: Group 1 was the control. Group 2 was only treated with cilostazol with a concentration of 10 mg/kg by intraperitoneal injection. Group 3 was exposed to 105 dB SPL with 4 kHz noise for 13 h. Group 4 was exposed to 105 dB SPL with 4 kHz noise for 13 h and then treated with 10 mg/kg cilostazol. After treatment, the cochlear blood flows and ABR thresholds of all groups were measured , respectively. Results Comparing to the control, the cochlear blood flow of Group 3 significantly decreased at 60, 90 and 120 min, afternoise exposure (P < 0.05). Comparing to Group 3, the cochlear blood flow of Group 4 significantly increased at 30, 60, 90 and 120 min, after drug treatment (P < 0.05). Comparing to the control, the ABR threshold of Group 3 significantly decreased after noise exposure (P < 0.05). Comparing to Gourp 3, the cochlear blood flow of Group 4 significantly increased after drug treatment (P < 0.01). Conclusion Cilostazol can effectively improve the cochlear blood flow and recover the ABR threshold shift of the guinea pigs after being exposed to intense noise.关键词
西洛他唑/噪声/耳蜗血流/ABR阈值Key words
Cilostazol/Noise/Cochlear blood flow/ ABR threshold引用本文复制引用
黄敏齐,张建国..西洛他唑对强噪声所致豚鼠耳蜗血流及听阈偏移的影响[J].实用医学杂志,2011,27(24):4385-4387,3.基金项目
广东省医学科研基金项目资助(编号:A2010259) （编号:A2010259）
