实用医学杂志2012，Vol.28Issue(3)：364-366,3.DOI:10.3969/j.issn.1006-5725.2012.03.009
黄芪多糖对压力超负荷诱导的大鼠心肌肥大的影响
Effect of Astragalus polysaccharides on cardiac hypertrophy induced by pressure overload in rat
摘要
Abstract
Objective To investigate the inhibition of the astragalus polysaccharides (APS) on cardiac hypertrophy induced by pressure overload in rat. Methods 60 SD rats were randomly divided into 5 groups:Sham, Model, Captopril, low-dose APS and high-dose APS group. All these drugs were administrated for 8 weeks respectively. Echocardiography and cardiac hypertrophy index were detected respectively for the heart function, HE staining was detected to observe the cardiac morphology. Results Echocardiography showed that compared with the sham group, left and right ventricular mass ratio (LVM/RVM) of the model group significantly increased, diastolic left ventricular volume (LV Vol, d), left ventricular ejection fraction (EF) and left ventricular fractional shortening rate (FS) of the model group decreased significantly. While comparing with the model group, the indexes of the above in APS group significantly improved. HE staining showed that myocardial cells became hypertrophic and arranged loosely in model group, while the myocardial cells in AP2 group arranged in order, and the hypertrophy cells obviously decreased. But there was no significant difference between the API and the model group. Conclusion APS has a high-dose group was significantly inhibited pressure overload cardiac hypertrophy in rats.关键词
黄芪多糖/压力超负荷/心肌肥大Key words
Astragalus polysaccharides/ Pressure overload/ Cardiac hypertrophy引用本文复制引用
李素娟,吴伟平,李杰锋,张贵平,魏毅,宜全,罗健东,刘英华..黄芪多糖对压力超负荷诱导的大鼠心肌肥大的影响[J].实用医学杂志,2012,28(3):364-366,3.基金项目
国家自然科学基金项目(编号:30901806) （编号:30901806）
广东省自然科学基金项目(编号:9451018201003650) （编号:9451018201003650）
广东高校优秀青年创新人才培养计划项目(编号:B103004) （编号:B103004）
广州市教育局项目(编号:10A155) （编号:10A155）
广州医学院博士启动基金项目(编号:2008C23) （编号:2008C23）
