实用医学杂志2012，Vol.28Issue(3)：392-395,4.DOI:10.3969/j.issn.1006-5725.2012.03.019
间歇性高容量血液滤过对严重脓毒症炎症介质的影响
Effects of pulse high-volume hemofiltration on inflammatory mediator in patients with severe sepsis and its clinical significance
摘要
Abstract
Objectives To investigate the effects of pulse high-volume hemofiltration (PHVHF) on serum levels of tumor necrosis factor (TNF-a), interleukin-6 (IL-6), and IL-10 in patients with severe sepsis, and to evaluate its clinical effects. Methods Forty patients with severe sepsis from Mar 2009 to Mar 2011 were included and randomly divided into control group (conventional treatment) and PHVHF group. Patients in PHVHF group received 72 h of PHVHF treatment in addition to conventional treatment after admission. The blood samples were taken before and 72 h after treatment to measure the changes of plasma levels of cytokines (TNF-a, IL-6, and IL-10). The acute physiology and chronic health evaluation II (APACHE II ) score, simplified acute physiology score (SAPS) and sequential organ failure assessment (SOFA) were observed at the same time. Results After 72 h of PHVHF treatment, there was an improvement in clinical features and hemodynamics variables in PHVHF group, and all the plasma levels of cytokines were significantly decreased (P< 0.05). In contrast, there was no significant change in control group (P> 0.05). Conclusions With the application of PHVHF treatment, plasma cytokines are effectively removed, and there was an improvement in clinical features and hemodynamics variables. PHVHF is a feasible adjuvant modality in the treatment of patients with severe sepsis.关键词
脓毒症/间歇性高容量血液滤过/炎症介质Key words
Sepsis/ Pulse high- volume hemofiltration/ Inflammatory mediator引用本文复制引用
邱泽亮,张宁,宁易平,徐俊龙,楼天正..间歇性高容量血液滤过对严重脓毒症炎症介质的影响[J].实用医学杂志,2012,28(3):392-395,4.基金项目
浙江省医药卫生科学研究基金资助项目(编号:20098171) （编号:20098171）
