摘要
Abstract
Objective To investigate the effectiveness and safety of early intravesical instillation of pirarubicin for prophylaxis of superficial bladder carcinoma after greenlight photoselective vaporization. Methods 117 patients diagnosed with superficial bladder carcinoma were treated by greenlight photoselective vaporization. The patients were randomly divided into two groups;63 patients were treated with intravesical instillation of pirarubicin within 6h after greenlight photoselective vaporization, followed by regular intravesical instillation (group I ) ; 54 were treated with regular intravesical instillation of pirarubicin one week after operation ( group II ). The patients were followed up for 14 to 52 months (mean 34 months); the recurrence rate, recurrence time and side effects were compared between the two groups. Results In group I , 8 cases had recurrence (12.7%), the time of recurrence was (684 ±221) days, no case relapsed in the first year, 5 cases in the second year and 3 cases after 2 years. In group II , 15 cases had recurrence (27.8% ) , the time of recurrence was (526 ±260) days, 5 cases relapsed in the first fellow-up year, 6 cases in the second year, 4 cases after 2 years. The recurrence rate and recurrence rate during the first fellow-up year were significantly lower in group I compared with those in group II (P<0.05). There were no significant differences in recurrence time, recurrence rate in the second year and after 2 years between the two groups. There was no difference in the incidence of side effects between the two groups. Conclusion Early intravesical instillation of pirarubicin after greenlight photoselective vaporization can reduce early recurrence of bladder cancer without increasing the incidence of side effects.关键词
膀胱中瘤/治疗/激光/多柔比星/治疗应用/化学疗法,肿瘤,局部灌注/投药,膀胱内/肿瘤复发,局部/预防和控制Key words
urinary bladder neoplasms/therapy/ lasers/ doxorubicin/therapeutic use/ chemotherapy, cancer, regional perfusion/ administration, intravesical/ neoplasm recurrence, local/prevention & control/ combined modality therapy分类
医药卫生
