生殖医学杂志2011，Vol.20Issue(6)：511-514,4.DOI:10.3969/j.issn.1004-3845.2011.06.018
吸液缓溶性壬苯醇醚膜对皮肤黏膜刺激性和抑菌作用的研究
The effects of imbibition-slow dissolving nonoxynol-9 membrane on skin/mucosal irritation and bacteriostasis
李荣秀 1李国正 1赵凯军 2高羽 2牛慧蒙 3赵慧芬1
作者信息
- 1. 河北省计划生育科学技术研究院,石家庄050071
- 2. 河北省藁城市人民医院,藁城052160
- 3. 河北省承德市双滦区人民医院,承德067000
- 折叠
摘要
Abstract
Objective: To investigate the effects of imbibition-slow dissolving nonoxynol-9 (NP-9) membrane on skin/mucosa irritation and bacteriostasis.Methods: In vivo rabbit skin/vaginal irritation test and in vitro bacteriostasis test were employed, with imbibition-slow dissolving NP-9 membran as test material, NP-9 membrane as positive control, and imbibition-slow dissolving membran without NP-9 as negative control.Results; The average skin irritation index by imbibition-slow dissolving NP-9 membrane was 0. The average irritation index of vaginal mucosal irritation test was 0. 7 by NP-9 membrane, and 0. 3 by imbibition-slow dissolving NP-9 membrane. In contact with imbibition-slow dissolving NP-9 membrane for 10 minutes, the bacteriostasis of staphylococcus aureus was observed. Five minutes of contact with the imbibition-slow dissolving NP-9 membrane resulted in a strong bacteriostasis of colibacillus and candidaalbicans. The NP-9 membrane had a weak bacteriostatic effect on colibacillus and staphylococcus aureus, but no bacteriostatic effect on candidaalbicans. The membrane matrix (without NP-9) had no antimicrobial effect.Conclusions: The imbibition-slow dissolving NP-9 membranes had no irritant effect on skin and its vaginal mucosal irritation was waker than that of NP-9 membrane. It had an obviously inhibitory effect on bacteria and fungi.关键词
吸液缓溶/壬苯醇醚-9(NP-9)/皮肤黏膜刺激/抑菌Key words
Imbibition-slow dissolving/Nonoxynol-9/ Mucosal irritation/Bacteriostasis引用本文复制引用
李荣秀,李国正,赵凯军,高羽,牛慧蒙,赵慧芬..吸液缓溶性壬苯醇醚膜对皮肤黏膜刺激性和抑菌作用的研究[J].生殖医学杂志,2011,20(6):511-514,4.
