摘要
Abstract
Gonadotrophin-releasing hormone agonist (GnRH-a) has been widely used in the pituitary down-regulation. There are two forms of GnRH-a, long- and short-acting. These two types of GnRH-a show comparable clinical efficacy? With good acceptability and patient compliance but risk of over suppression of ovary for long-acting form, while disadvantages in acceptability and patient compliance for short-acting form. There are several protocols for down-regulation in clinical application, including long, super-long, short and super-short protocols, with different advantages and disadvantages. In general, the individualized protocol is the best one. As the identification of down-regulation is controversial, the timing of initiation of gonadotropin administration is different in different reproductive center or in different studies, which is largely dependent on the down-regulation protocols used and patient characteristics. In some existing evidence, delayed initiation showed no detrimental effects on the treatment outcomes, but may improve the quality of retrieved oocytes and endometrial receptibility, resulting in a higher pregnancy rate. In addition, the properly delayed initiation of gonadotropin administration could reduce the ampules of gonadotropin used, offering an economic benefit for the patients.关键词
促性腺激素释放激素激动剂/垂体降调节/促性腺激素/个体化Key words
Gonadotrophin-releasing hormone agonist/ Pituitary down-regulation/ Gonadotropin/ Individualization
