天津中医药2011，Vol.28Issue(6)：454-456,3.
消渴肾方对早期糖尿病肾病血液流变学、尿白蛋白排泄率及血浆内皮素1的影响
Effect of Xiaokeshen prescription on blood hemorheology, urinary albumin excretion rate and endothelin 1 in patients with early diabetic nephropathy
摘要
Abstract
[Objective] To observe the effect of Xiaokeshen prescription on blood hemorheology, urinary albumin excretion rate and endothelin 1 in patients with early diabetic nephropathy. [Methods] Seventy-four patients were randomly divided into two groups: treatment group (37cases) and control group (37cases). The patients of two groups were received the same basic treatment including diet control and hypoglycemic therapy. The treatment group was given with Xiaokeshen prescription simultaneously and the control group was given with Cozaar. After treatment for four months and a half the hemorheology, urinary albumin excretion rate and endothelin 1 were detected. [Results] After treatment, indexes of hemorheology in treatment group were obviously decreased (P<0.05) and better than that in the control group (P<0.05). There was a statistical significance in urinary albumin excretion rate and endothelin 1 after treatment in both groups (P<0.05). But there was no statistical significance between two groups (P>0.05). [Conclusion] Xiaokeshen prescription can improve hemorheology, decrease endothelin 1, and reduce the excluding content of plasma urinary albumin in patients with DN. Xiaokeshen prescription has significant curative effect on patient with DN.关键词
消渴肾方/糖尿病肾病/血液流变学/尿白蛋白/血浆内皮素1(ET-1)Key words
Xiaokeshen prescription/ diabetic nephropathy/ hemorheology/ proteinuria/ endothelin 1分类
医药卫生引用本文复制引用
马丽,车树强..消渴肾方对早期糖尿病肾病血液流变学、尿白蛋白排泄率及血浆内皮素1的影响[J].天津中医药,2011,28(6):454-456,3.基金项目
国家科技支撑计划项目(2007BAI10B01-006). （2007BAI10B01-006）
