同位素2011，Vol.24Issue(4)：198-204,7.
(N-[18F]氟甲基)胆碱的半自动合成和无菌型炎症PET显像评价
Semi-automatic Synthesis and PET Imaging Evaluation of 18F-fluoromethylcholine With the Aseptic Inflammation Model
摘要
Abstract
Semi-automated synthesis of 18F-fluoromethylcholine (18 F-FCH) was achieved with the modification of the commercial synthesis model and the PET imaging of aseptic inflammation model was performed with 18 F-FCH. 18FCH2Br as a [18F]fluoromethylation a-gent was prepared by the fluorination of dibromomethane followed by distillation from the reaction vessel. The obtained 18FCH2Br then reacted with N, N-dimethylamino ethanol loaded on the Sep Pak tC18 cartridge to give 18 F-FCH. After being purified on the solid-phase extraction cartridges? 18F-FCH was obtained with 12%±2% radiochemical yields (n = 3, decay not corrected), and higher than 95% radiochemical purity. The synthesis time was less than 35 min. PET imaging showed that 18 F-FCH had a slightly lower uptake than 18F-FDG in the inflammation tissues infected with turpentine oil, suggesting a potential use of 18F-FCH to differentiate between a tumor and inflammation by PET imaging.关键词
[18F]氟甲基胆碱/炎症/18F-FDG/PET显像Key words
18F-fluoromethylcholine(18F-FCH)/ inflammation/ 18F-FDG/ PET imaging分类
医药卫生引用本文复制引用
王红亮,黄婷婷,梁祥,吴克宁,唐刚华..(N-[18F]氟甲基)胆碱的半自动合成和无菌型炎症PET显像评价[J].同位素,2011,24(4):198-204,7.基金项目
国家高科技计划(863计划)专题课题(2008AA02Z430) （863计划）
国际原子能机构资助项目(15245/RO) （15245/RO）
