武汉工程大学学报2011，Vol.33Issue(10)：13-16,4.DOI:10.3969/j.issn.1674-2869.2011.10.004
半富马酸喹硫平的合成
Synthesis of quetiapine hemifumarate
明娟 1杨艺虹 1张珩 1张国龙1
作者信息
- 1. 武汉工程大学绿色化工过程省部共建教育部重点实验室,湖北武汉430074
- 折叠
摘要
Abstract
The synthetic routes had been studied for 10H-dibenzo[b,f][l,4]thiazepine-ll-ketone(4), which was synthesized using thiosalicylic acid and o-chloro-nitrobenzene as starting materials,2-amino-2 -carboxyl diphenylsulfided) was synthesized in aqueous phase,which was reduced by iron powder and cyclized in the polyphosphoric acid. Quetiapine Hemifumarate(l) was produced from 4,in the process of chlorination with phosphorus oxychloride.condensed with piperazine and 2-amino-4-chloro- pyrimidine (6),salt formed with fumaric acid in ethyl alcohol. The total yield was 47. 60%. The structrue was confirmed by IR and 1H NMR.关键词
抗精神病药/半富马酸喹硫平/合成工艺Key words
antipsychotic drug/quetiapine hemifumarate/synthesis study分类
化学化工引用本文复制引用
明娟,杨艺虹,张珩,张国龙..半富马酸喹硫平的合成[J].武汉工程大学学报,2011,33(10):13-16,4.
