武汉工程大学学报2011，Vol.33Issue(11)：27-30,4.DOI:10.3969/j.issn.1674-2869.2011.11.007
头孢克肟固体分散体的制备及溶出度测定
Preparation and dissolution of cefixime solid dispersion
严少康 1刘永红 2黎璐平 1肖芳 1刘永琼1
作者信息
- 1. 武汉工程大学化工与制药学院,绿色化工过程省部共建教育部重点实验室,湖北省新型反应器与绿色化学工艺重点实验室,湖北 武汉 430074
- 2. 湖北省襄樊市中心医院,湖北 襄樊 441021
- 折叠
摘要
Abstract
The technology of solid dispersion to improve the dissolution of cefixime and its bioavailability was used. Taking A as the carrier,using solvent-melting method to prepare the cefixime solid diapersion and using orthogonal design to perfect preparation technology, the best prescription was cefixime : carrierA:alcohol=1:4:8 (g/g/g). Choosing the technology of infrared spectrum to identify the phase of cefixime solid diapersion and determine its dissolution,the result shows that the dissolution of cefixime-carrierA(1:4) solid dispersion 95. 2% is obviousiy exceeding the active pharmaceutical ingredient 24.8% and physics mixture 28. 6%. Using solvent-melting method can shape solid diapersion better which was explained by the detection of infrared spectrum. The strength of Cefixime and carrier's crystalloid absorption peak dropped drastically at 1 780 cm-1. The conclusion is that the dissolution can be improved when cefixime formed solid diapersion.关键词
头孢克肟/固体分散体/制备/溶出度/红外光谱Key words
cefixime/solid diapersion/preparation/dissolution/infrared spectrum分类
化学化工引用本文复制引用
严少康,刘永红,黎璐平,肖芳,刘永琼..头孢克肟固体分散体的制备及溶出度测定[J].武汉工程大学学报,2011,33(11):27-30,4.
