武警医学2012，Vol.23Issue(2)：97-101,5.
去甲肾上腺素在肝移植手术中的应用
Effect of norepinephrine in patients undergoing orthotopic liver transplantation
雷志礼 1董兰 1韩曙君 1宇鹏 1宁新宇 1陈晖1
作者信息
摘要
Abstract
Objective To evaluate the effect of norepinephrine on hemodynamic, renal function and myocardial enzymes in patients undergoing orthotopic liver transplantation. Methods Forty adult patients undergoing orthotopic liver transplantation were randomly divided into two groups: norepinephrine group ( group N) and dopamine group ( group D) ( n = 20) . Hemodynamic variables, renal function and myocardial enzymes were measured respectively just before incision (T1) , at 1 h after incision (T2 ) , 30 min after the clamping of the portal vein ( T3 ) , 1 h ( T4 ) and 4 h ( T5 ) after the unclamping of the portal vein. Results Mean arterial pressure (MAP) was maintained to the target in both groups during the operation. Group N showed high MAP and low heart rate(HR) at T3 , compared with group D(P <0. 05) . Β2 - MG in group N was significantly lower than that in group D at T2 (P <0. 05) . Compared with T1, only CK increased significantly at T3 (P <0. 05) , so did all the enzymes at T4_5 (P <0. 05) . Conclusions Norepinephrine can maintain hemodynamic stability with low HR in patients undergoing orthotopic liver transplantation, without any deleterious effects on renal function and myocardial enzymes.关键词
去甲肾上腺素/肝移植/血流动力学/肾功能/心肌酶Key words
norepinephrine/ liver transplantation/ hemodynamics / renal function/ myocardial enzymes分类
药学引用本文复制引用
雷志礼,董兰,韩曙君,宇鹏,宁新宇,陈晖..去甲肾上腺素在肝移植手术中的应用[J].武警医学,2012,23(2):97-101,5.
